RT Journal Article
T1 Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study.
A1 Miravitlles, Marc
A1 Soler-Cataluña, Juan José
A1 Soriano, Joan B
A1 García-Río, Francisco
A1 de Lucas, Pilar
A1 Alfageme, Inmaculada
A1 Casanova, Ciro
A1 Rodríguez González-Moro, José Miguel
A1 Sánchez-Herrero, M Guadalupe
A1 Ancochea, Julio
A1 Cosío, Borja G
K1 Biomarkers
K1 Computed tomography
K1 Epidemiology
K1 Imaging population
AB Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil count (BEC) in individuals with and without COPD. EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general population, and COPD was defined by a post-bronchodilator FEV1/FVC  A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard deviation [SD]) was 63.2 years (11.0), 46.3% were male, and 27.6% were active smokers. BEC was significantly higher in individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p = 0.0003]. In a stepwise multivariate model, being male, active smoker and having a previous diagnosis of asthma were independently associated with having a higher BEC. This population-based study estimated the distribution of eosinophils in the healthy adult population and concluded that COPD patients have a significantly higher BEC. Male sex, active smoking and concomitant asthma were significantly associated with a higher BEC.
YR 2022
FD 2022-03-05
LK http://hdl.handle.net/10668/20313
UL http://hdl.handle.net/10668/20313
LA en
DS RISalud
RD Apr 8, 2025