%0 Journal Article
%A Miravitlles, Marc
%A Soler-Cataluña, Juan José
%A Soriano, Joan B
%A García-Río, Francisco
%A de Lucas, Pilar
%A Alfageme, Inmaculada
%A Casanova, Ciro
%A Rodríguez González-Moro, José Miguel
%A Sánchez-Herrero, M Guadalupe
%A Ancochea, Julio
%A Cosío, Borja G
%T Determinants of blood eosinophil levels in the general population and patients with COPD: a population-based, epidemiological study.
%D 2022
%U http://hdl.handle.net/10668/20313
%X Blood eosinophils are considered a biomarker for the treatment of chronic obstructive pulmonary disease (COPD). Population-based studies are needed to better understand the determinants of the blood eosinophil count (BEC) in individuals with and without COPD. EPISCAN II is a multicentre, cross-sectional, population-based epidemiological study aimed at investigating the prevalence and determinants of COPD in Spain. Study subjects were randomly selected from the general population, and COPD was defined by a post-bronchodilator FEV1/FVC  A total of 326 COPD and 399 non-COPD subjects were included in the analysis. The mean age (standard deviation [SD]) was 63.2 years (11.0), 46.3% were male, and 27.6% were active smokers. BEC was significantly higher in individuals with COPD [192 cells/μL (SD: 125) vs. 160 cells/μL (SD: 114); p = 0.0003]. In a stepwise multivariate model, being male, active smoker and having a previous diagnosis of asthma were independently associated with having a higher BEC. This population-based study estimated the distribution of eosinophils in the healthy adult population and concluded that COPD patients have a significantly higher BEC. Male sex, active smoking and concomitant asthma were significantly associated with a higher BEC.
%K Biomarkers
%K Computed tomography
%K Epidemiology
%K Imaging population
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