RT Journal Article
T1 Overproduction of Outer Membrane Protein A by Acinetobacter baumannii as a Risk Factor for Nosocomial Pneumonia, Bacteremia, and Mortality Rate Increase.
A1 Sánchez-Encinales, Viviana
A1 Álvarez-Marín, Rocío
A1 Pachón-Ibáñez, María Eugenia
A1 Fernández-Cuenca, Felipe
A1 Pascual, Alvaro
A1 Garnacho-Montero, José
A1 Martínez-Martínez, Luis
A1 Vila, Jordi
A1 Tomás, María Mar
A1 Cisneros, José Miguel
A1 Bou, Germán
A1 Rodríguez-Baño, Jesús
A1 Pachón, Jerónimo
A1 Smani, Younes
K1 Acinetobacter baumannii
K1 bacteremia
K1 mortality
K1 pneumonia
K1 OmpA
AB Outer membrane protein A (OmpA) is a porin involved in Acinetobacter baumannii pathogenesis. However, OmpA clinical implication in hospital-acquired infections remains unknown. We aimed to determine whether OmpA overproduction was a risk factor associated with pneumonia, bacteremia, and mortality. We analyzed demographic, microbiological, and clinical data from 100 patients included in a unicenter cohort and 246 included in a unicenter cohort and a multicenter cohort. Representative isolates were classified into 2 groups: (1) isolates from patients colonized by A. baumannii (16 from the unicenter and 20 from the multicenter cohort) and (2) isolates from bacteremic or nonbacteremic patients with pneumonia (PP) caused by A. baumannii (13 from the unicenter and 23 from the multicenter cohort) Expression of ompA was determined with quantitative reverse-transcription polymerase chain reaction. Isolates from PP overexpressed more ompA than those from colonized patients from the unicenter (ratio, 1.76 vs 0.36; P  These data suggest that ompA overexpression is an associated factor for pneumonia, bacteremia, and death due to A. baumannii.
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11147
UL http://hdl.handle.net/10668/11147
LA en
DS RISalud
RD Apr 10, 2025