RT Journal Article
T1 Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study.
A1 Ricci, Cristian
A1 Wood, Angela
A1 Muller, David
A1 Gunter, Marc J
A1 Agudo, Antonio
A1 Boeing, Heiner
A1 van der Schouw, Yvonne T
A1 Warnakula, Samantha
A1 Saieva, Calogero
A1 Spijkerman, Annemieke
A1 Sluijs, Ivonne
A1 Tjønneland, Anne
A1 Kyrø, Cecilie
A1 Weiderpass, Elisabete
A1 Kühn, Tilman
A1 Kaaks, Rudolf
A1 Sanchez-Perez, Maria-Jose
A1 Panico, Salvatore
A1 Agnoli, Claudia
A1 Palli, Domenico
A1 Tumino, Rosario
A1 Engström, Gunnar
A1 Melander, Olle
A1 Bonnet, Fabrice
A1 Boer, Jolanda M A
A1 Key, Timothy J
A1 Travis, Ruth C
A1 Overvad, Kim
A1 Verschuren, W M Monique
A1 Quirós, J Ramón
A1 Trichopoulou, Antonia
A1 Papatesta, Eleni-Maria
A1 Peppa, Eleni
A1 Iribas, Conchi Moreno
A1 Gavrila, Diana
A1 Forslund, Ann-Sofie
A1 Jansson, Jan-Håkan
A1 Matullo, Giuseppe
A1 Arriola, Larraitz
A1 Freisling, Heinz
A1 Lassale, Camille
A1 Tzoulaki, Ioanna
A1 Sharp, Stephen J
A1 Forouhi, Nita G
A1 Langenberg, Claudia
A1 Saracci, Rodolfo
A1 Sweeting, Michael
A1 Brennan, Paul
A1 Butterworth, Adam S
A1 Riboli, Elio
A1 Wareham, Nick J
A1 Danesh, John
A1 Ferrari, Pietro
AB To investigate the association between alcohol consumption (at baseline and over lifetime) and non-fatal and fatal coronary heart disease (CHD) and stroke. Multicentre case-cohort study. A study of cardiovascular disease (CVD) determinants within the European Prospective Investigation into Cancer and nutrition cohort (EPIC-CVD) from eight European countries. 32 549 participants without baseline CVD, comprised of incident CVD cases and a subcohort for comparison. Non-fatal and fatal CHD and stroke (including ischaemic and haemorrhagic stroke). There were 9307 non-fatal CHD events, 1699 fatal CHD, 5855 non-fatal stroke, and 733 fatal stroke. Baseline alcohol intake was inversely associated with non-fatal CHD, with a hazard ratio of 0.94 (95% confidence interval 0.92 to 0.96) per 12 g/day higher intake. There was a J shaped association between baseline alcohol intake and risk of fatal CHD. The hazard ratios were 0.83 (0.70 to 0.98), 0.65 (0.53 to 0.81), and 0.82 (0.65 to 1.03) for categories 5.0-14.9 g/day, 15.0-29.9 g/day, and 30.0-59.9 g/day of total alcohol intake, respectively, compared with 0.1-4.9 g/day. In contrast, hazard ratios for non-fatal and fatal stroke risk were 1.04 (1.02 to 1.07), and 1.05 (0.98 to 1.13) per 12 g/day increase in baseline alcohol intake, respectively, including broadly similar findings for ischaemic and haemorrhagic stroke. Associations with cardiovascular outcomes were broadly similar with average lifetime alcohol consumption as for baseline alcohol intake, and across the eight countries studied. There was no strong evidence for interactions of alcohol consumption with smoking status on the risk of CVD events. Alcohol intake was inversely associated with non-fatal CHD risk but positively associated with the risk of different stroke subtypes. This highlights the opposing associations of alcohol intake with different CVD types and strengthens the evidence for policies to reduce alcohol consumption.
YR 2018
FD 2018-05-29
LK http://hdl.handle.net/10668/12516
UL http://hdl.handle.net/10668/12516
LA en
DS RISalud
RD Apr 7, 2025