RT Journal Article
T1 The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure.
A1 Martin-Loeches, Ignacio
A1 Muriel-Bombín, Arturo
A1 Ferrer, Ricard
A1 Artigas, Antonio
A1 Sole-Violan, Jordi
A1 Lorente, Leonardo
A1 Andaluz-Ojeda, David
A1 Prina-Mello, Adriele
A1 Herrán-Monge, Ruben
A1 Suberviola, Borja
A1 Rodriguez-Fernandez, Ana
A1 Merino, Pedro
A1 Loza, Ana M
A1 Garcia-Olivares, Pablo
A1 Anton, Eduardo
A1 Tamayo, Eduardo
A1 Trapiello, Wysali
A1 Blanco, Jesús
A1 Bermejo-Martin, Jesús F
A1 GRECIA group, 
K1 Immunoglobulins
K1 Sepsis
K1 Severity
K1 Survival
AB Pre-evaluation of endogenous immunoglobulin levels is a potential strategy to improve the results of intravenous immunoglobulins in sepsis, but more work has to be done to identify those patients who could benefit the most from this treatment. The objective of this study was to evaluate the impact of endogenous immunoglobulins on the mortality risk in sepsis depending on disease severity. This was a retrospective observational study including 278 patients admitted to the ICU with sepsis fulfilling the SEPSIS-3 criteria, coming from the Spanish GRECIA and ABISS-EDUSEPSIS cohorts. Patients were distributed into two groups depending on their Sequential Organ Failure Assessment score at ICU admission (SOFA  ICU/hospital mortality in the SOFA  Endogenous immunoglobulin levels may have a different impact on the mortality risk of sepsis patients based on their severity. In patients with moderate organ failure, the simultaneous presence of low levels of IgG, IgA and IgM was a consistent predictor of both acute and post-acute mortalities.
SN 2110-5820
YR 2017
FD 2017-04-20
LK http://hdl.handle.net/10668/11122
UL http://hdl.handle.net/10668/11122
LA en
DS RISalud
RD Apr 12, 2025