RT Journal Article
T1 Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study.
A1 Navarrete-Muñoz, Eva-Maria
A1 Vioque, Jesus
A1 Toledo, Estefanía
A1 Oncina-Canovas, Alejando
A1 Martínez-González, Miguel Ángel
A1 Salas-Salvadó, Jordi
A1 Corella, Dolores
A1 Fitó, Montserrat
A1 Romaguera, Dora
A1 Alonso-Gómez, Ángel M
A1 Wärnberg, Julia
A1 Martínez, J Alfredo
A1 Serra-Majem, Luís
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, José
A1 Pintó, Xavier
A1 Tur, Josep A
A1 López-Miranda, José
A1 Bueno-Cavanillas, Aurora
A1 Matía-Martín, Pilar
A1 Daimiel, Lidia
A1 Sánchez, Vicente Martín
A1 Vidal, Josep
A1 de Cos Blanco, Ana Isabel
A1 Ros, Emili
A1 Diez-Espino, Javier
A1 Babio, Nancy
A1 Fernandez-Carrion, Rebeca
A1 Castañer, Olga
A1 Colom, Antoni
A1 Compañ-Gabucio, Laura
A1 Lete, Itziar Salaverria
A1 Crespo-Oliva, Edelys
A1 Abete, Itziar
A1 Tomaino, Laura
A1 Casas, Rosa
A1 Fernandez-Garcia, José Carlos
A1 Santos-Lozano, José Manuel
A1 Sarasa, Iziar
A1 Gámez, José M
A1 Garcia-Rios, José M Antonio
A1 Martín-Pelaez, Sandra
A1 Ruiz-Canela, Miguel
A1 Díaz-López, Andrés
A1 Martinez-Lacruz, Raul
A1 Zomeño, Maria Dolors
A1 Rayó, Elena
A1 Sellés, Cristina Gisbert
A1 Canudas, Silvia
A1 Goday, Albert
A1 García-de-la-Hera, Manoli
K1 Cardiometabolic risk
K1 Cholesterol
K1 Diabetes
K1 Folate
K1 Metabolic syndrome score
AB We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
YR 2020
FD 2020-08-24
LK http://hdl.handle.net/10668/16141
UL http://hdl.handle.net/10668/16141
LA en
DS RISalud
RD Apr 18, 2025