RT Journal Article
T1 Solving the preoperative breast MRI conundrum: design and protocol of the MIPA study.
A1 Sardanelli, Francesco
A1 Trimboli, Rubina M
A1 Houssami, Nehmat
A1 Gilbert, Fiona J
A1 Helbich, Thomas H
A1 Alvarez Benito, Marina
A1 Balleyguier, Corinne
A1 Bazzocchi, Massimo
A1 Bult, Peter
A1 Calabrese, Massimo
A1 Camps Herrero, Julia
A1 Cartia, Francesco
A1 Cassano, Enrico
A1 Clauser, Paola
A1 de Andrade, Danubia A
A1 de Lima Docema, Marcos F
A1 Depretto, Catherine
A1 Forrai, Gabor
A1 Girometti, Rossano
A1 Harms, Steven E
A1 Hilborne, Sarah
A1 Ienzi, Raffaele
A1 Lobbes, Marc B I
A1 Losio, Claudio
A1 Mann, Ritse M
A1 Montemezzi, Stefania
A1 Obdeijn, Inge-Marie
A1 Ozcan, Umit Aksoy
A1 Pediconi, Federica
A1 Preibsch, Heike
A1 Raya-Povedano, José L
A1 Sacchetto, Daniela
A1 Scaperrotta, Gianfranco P
A1 Schlooz, Margrethe
A1 Szabo, Botond K
A1 Ulus, Ozden S
A1 Taylor, Donna B
A1 Van Goethem, Mireille
A1 Veltman, Jeroen
A1 Weigel, Stefanie
A1 Wenkel, Evelyn
A1 Zuiani, Chiara
A1 Di Leo, Giovanni
K1 Breast neoplasms
K1 Breast-conserving surgery
K1 Magnetic resonance imaging
K1 Mastectomy
K1 Prospective studies
AB Despite its high diagnostic performance, the use of breast MRI in the preoperative setting is controversial. It has the potential for personalized surgical management in breast cancer patients, but two of three randomized controlled trials did not show results in favor of its introduction for assessing the disease extent before surgery. Meta-analyses showed a higher mastectomy rate in women undergoing preoperative MRI compared to those who do not. Nevertheless, preoperative breast MRI is increasingly used and a survey from the American Society of Breast Surgeons showed that 41% of respondents ask for it in daily practice. In this context, a large-scale observational multicenter international prospective analysis (MIPA study) was proposed under the guidance of the European Network for the Assessment of Imaging in Medicine (EuroAIM). The aims were (1) to prospectively and systematically collect data on consecutive women with a newly diagnosed breast cancer, not candidates for neoadjuvant therapy, who are offered or not offered breast MRI before surgery according to local practice; (2) to compare these two groups in terms of surgical and clinical endpoints, adjusting for covariates. The underlying hypotheses are that MRI does not cause additional mastectomies compared to conventional imaging, while reducing the reoperation rate in all or in subgroups of patients. Ninety-six centers applied to a web-based call; 36 were initially selected based on volume and quality standards; 27 were active for enrollment. On November 2018, the target of 7000 enrolled patients was reached. The MIPA study is presently at the analytic phase. Key Points • Breast MRI has a high diagnostic performance but its utility in the preoperative setting is controversial. • A large-scale observational multicenter prospective study was launched to compare women receiving with those not receiving preoperative MRI. • Twenty-seven centers enrolled more than 7000 patients. The study is presently at the analytic phase.
YR 2020
FD 2020-05-06
LK http://hdl.handle.net/10668/15525
UL http://hdl.handle.net/10668/15525
LA en
DS RISalud
RD Apr 6, 2025