RT Journal Article
T1 Cytokines and Inflammation in Meniere Disease.
A1 Frejo, Lidia
A1 Lopez-Escamez, Jose Antonio
K1 Autoimmunity
K1 Autoinflammatory Disease
K1 Cytokines
K1 Meniere Disease
K1 Vestibular Disease
AB Meniere disease (MD) is a rare set of conditions associated with the accumulation of endolymph in the cochlear duct and the vestibular labyrinth with a decrease of endocochlear potential. It is considered a chronic inflammatory disorder of the inner ear with a multifactorial origin. The clinical syndrome includes several groups of patients with a core phenotype: sensorineural hearing loss, episodes of vertigo, and tinnitus with a non-predictable course. Genetic factors and the innate immune response seem to play a central role in the pathophysiology of the condition. Autoimmune MD should be diagnosed if a patient fulfills the diagnostic criteria for MD and one of the following autoimmune disorders: autoimmune thyroid disease, psoriasis, autoimmune arthritis, ankylosing spondylitis, or systemic lupus erythematosus. We summarize the evidence to support autoimmune MD as an endophenotype in bilateral MD associated with the allelic variant rs4947296 and nuclear factor-kappa B (NF-κB)-mediated inflammation, the role of cytokines (particularly interleukin-1β and tumor necrosis factor-α) in defining a subset of patients with autoinflammation, and the potential role of cytokines as biomarkers to distinguish between patients with MD and vestibular migraine. Finally, we also introduce a list of potential drugs that could regulate the immune response in MD with potential for repurposing in clinical trials.
PB Korean Society of Otorhinolaryngology-Head and Neck Surgery,Daehan Ibi-inhugwa Haghoe
SN 1976-8710
YR 2022
FD 2022-02-11
LK http://hdl.handle.net/10668/21778
UL http://hdl.handle.net/10668/21778
LA en
NO Frejo L, Lopez-Escamez JA. Cytokines and Inflammation in Meniere Disease. Clin Exp Otorhinolaryngol. 2022 Feb;15(1):49-59.
NO We acknowledge all patients and participants in the Meniere Disease Consortium (MeDiC). Jose Antonio Lopez-Escamez has received funds to support research on the immune response in Meniere disease from Instituto de Salud Carlos III and European Regional Funds (grants no. PI17/1644 and PI20-1126) and the Andalusian Health Department (grants no. PE-0356-2018 and PI027-2020).
DS RISalud
RD Apr 19, 2025