RT Journal Article
T1 Evaluation of criteria for clinical control in a prospective, international, multicenter study of patients with COPD.
A1 Miravitlles, Marc
A1 Sliwinski, Pawel
A1 Rhee, Chin Kook
A1 Costello, Richard W
A1 Carter, Victoria
A1 Tan, Jessica
A1 Lapperre, Therese Sophie
A1 Alcazar, Bernardino
A1 Gouder, Caroline
A1 Esquinas, Cristina
A1 García-Rivero, Juan Luis
A1 Kemppinen, Anu
A1 Tee, Augustine
A1 Roman-Rodríguez, Miguel
A1 Soler-Cataluña, Juan José
A1 Price, David B
K1 CAT
K1 CCQ
K1 COPD
K1 Control
K1 Outcomes
AB The concept of clinical control in COPD has been developed to help in treatment decisions, but it requires validation in prospective studies. This international, multicenter, prospective study aimed to validate the concept of control in COPD [control = stability (no exacerbations or impairment in CAT scores) + low impact (low level of symptoms)]. Data from the screening visit was used to: investigate the level of control, compare characteristics of patients according to the control status, and perform a sensitivity analysis of the levels of control using either clinical criteria or questionnaires (COPD Assessment Test -CAT- or Clinical COPD Questionnaire -CCQ-). A total of 314 patients were analysed, mean age was 68.5 years and mean FEV1 was 52.6% of predicted. According to the prespecified criteria 21% of patients were classified as controlled, all of them with mild/moderate COPD (Body mass index, Obstruction, Dyspnea and Exacerbations, -BODEx-index  The proposed criteria of control were only fulfilled by 21% of patients. The suggested cut offs and their predictive value for poor outcomes need to be refined in prospective studies.
YR 2018
FD 2018-01-31
LK https://hdl.handle.net/10668/24830
UL https://hdl.handle.net/10668/24830
LA en
DS RISalud
RD Apr 18, 2025