TY - JOUR AU - Barrionuevo, Francisco J. AU - Hurtado, Alicia AU - Kim, Gwang-Jin AU - Real, Francisca M. AU - Bakkali, Mohammed AU - Kopp, Janel L. AU - Sander, Maike AU - Scherer, Gerd AU - Burgos, Miguel AU - Jimenez, Rafael PY - 2016 DO - 10.7554/eLife.15635 SN - 2050-084X UR - http://hdl.handle.net/10668/19394 T2 - Elife AB - The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation. Dmrt1 plays a similar role in... LA - en PB - Elife sciences publications ltd KW - Autosomal sex reversal KW - Sry-related gene KW - Campomelic dysplasia KW - Mammalian testis KW - Sertoli-cells KW - Transcription factors KW - Male-fertility KW - Beta-catenin KW - Iberian mole KW - Expression KW - Mice KW - Animals KW - Female KW - Male KW - Anorchia KW - Testis KW - Sertoli Cells KW - Ovary KW - DMRT1 protein KW - Leydig Cells KW - Gonads KW - Seminiferous Tubules KW - Fertility KW - Apoptosis TI - Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration TY - research article VL - 5 ER -