TY  - JOUR
AU  - Martinez-Macias, Maria Isabel
AU  - Moore, Duncan Aq
AU  - Green, Ryan L
AU  - Gomez-Herreros, Fernando
AU  - Naumann, Marcel
AU  - Hermann, Andreas
AU  - Van Damme, Philip
AU  - Hafezparast, Majid
AU  - Caldecott, Keith W
PY  - 2019
DO  - 10.26508/lsa.201800222
UR  - http://hdl.handle.net/10668/13629
T2  - Life science alliance
AB  - FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases. Here, we show that FUS is a component of the cellular response to topoisomerase I...
LA  - en
KW  - A549 Cells
KW  - Amyotrophic Lateral Sclerosis
KW  - Animals
KW  - Binding Sites
KW  - Brain
KW  - Chromatin
KW  - DNA Breaks, Double-Stranded
KW  - DNA Repair
KW  - DNA Topoisomerases, Type I
KW  - Fibroblasts
KW  - HeLa Cells
KW  - Humans
KW  - Mice
KW  - Mutant Proteins
KW  - Mutation
KW  - Neural Stem Cells
KW  - Neurons
KW  - RNA Polymerase I
KW  - RNA Polymerase II
KW  - RNA-Binding Protein FUS
KW  - Transcription, Genetic
TI  - FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I-induced DNA breakage and transcriptional stress.
TY  - research article
VL  - 2
ER  -