RT Journal Article
T1 New candidate blood biomarkers potentially associated with white matter hyperintensities progression.
A1 Jiménez-Balado, Joan
A1 Pizarro, Jesús
A1 Riba-Llena, Iolanda
A1 Penalba, Anna
A1 Faura, Júlia
A1 Palà, Elena
A1 Montaner, Joan
A1 Hernández-Guillamon, Mar
A1 Delgado, Pilar
AB We aimed to discover blood biomarkers associated with longitudinal changes in white matter hyperintensities (WMH). This study was divided into a discovery phase and a replication phase. Subjects in both studies were patients with hypertension, aged 50-70, who underwent two magnetic resonance imaging (MRI) sessions and blood extractions over a 4-year follow-up period. In the discovery phase, we screened 1305 proteins in 12 subjects with WMH progression and in 12 matched control subjects. We found that 41 proteins were differentially expressed: 13 were upregulated and 28 were downregulated. We subsequently selected three biomarkers for replication in baseline and follow-up samples in 80 subjects with WMH progression and in 80 control subjects. The selected protein candidates for the replication were MMP9 (matrix metalloproteinase-9), which was higher in cases, MET (hepatocyte growth factor receptor) and ASAH2 (neutral ceramidase), which were both lower in cases of WMH progression. Baseline biomarker concentrations did not predict WMH progression. In contrast, patients with WMH progression presented a steeper decline in MET over time. Furthermore, cases showed higher MMP9 and lower ASAH2 levels than controls at the follow-up. These results indicate that MMP9, MET, and ASAH2 are potentially associated with the progression of WMH, and could therefore be interesting candidates to validate in future studies.
YR 2021
FD 2021-07-12
LK http://hdl.handle.net/10668/18193
UL http://hdl.handle.net/10668/18193
LA en
DS RISalud
RD Apr 6, 2025