TY  - JOUR
AU  - Burgos-Barragan, Guillermo
AU  - Wit, Niek
AU  - Meiser, Johannes
AU  - Dingler, Felix A
AU  - Pietzke, Matthias
AU  - Mulderrig, Lee
AU  - Pontel, Lucas B
AU  - Rosado, Ivan V
AU  - Brewer, Thomas F
AU  - Cordell, Rebecca L
AU  - Monks, Paul S
AU  - Chang, Christopher J
AU  - Vazquez, Alexei
AU  - Patel, Ketan J
PY  - 2017
DO  - 10.1038/nature23481
UR  - http://hdl.handle.net/10668/11508
T2  - Nature
AB  - The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic modifications. This cycle might also release formaldehyde, a potent protein and DNA crosslinking...
LA  - en
KW  - Alcohol Dehydrogenase
KW  - Animals
KW  - Carbon
KW  - Cell Line
KW  - Chickens
KW  - Coenzymes
KW  - Cross-Linking Reagents
KW  - DNA Damage
KW  - DNA Repair
KW  - Folic Acid
KW  - Formaldehyde
KW  - Humans
KW  - Inactivation, Metabolic
KW  - Metabolic Networks and Pathways
KW  - Mice
KW  - Mutagens
KW  - Nucleotides
KW  - Oxidation-Reduction
KW  - Serine
KW  - Tetrahydrofolates
TI  - Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism.
TY  - research article
VL  - 548
ER  -