TY  - JOUR
AU  - Stephens, Camilla
AU  - López-Nevot, Miguel-Ángel
AU  - Ruiz-Cabello, Francisco
AU  - Ulzurrun, Eugenia
AU  - Soriano, Germán
AU  - Romero-Gómez, Manuel
AU  - Moreno-Casares, Antonia
AU  - Lucena, M Isabel
AU  - Andrade, Raul J
PY  - 2013
DO  - 10.1371/journal.pone.0068111
UR  - http://hdl.handle.net/10668/1272
T2  - PloS One
AB  - BACKGROUND AND AIMThe genotype-phenotype interaction in drug-induced liver injury (DILI) is a subject of growing interest. Previous studies have linked amoxicillin-clavulanate (AC) hepatotoxicity susceptibility to specific HLA alleles. In this study...
LA  - en
PB  - Public Library of Science
KW  - Combinación Amoxicilina-Clavulanato de Potasio
KW  - Enfermedad Hepática Inducida por Drogas
KW  - Predisposición Genética a la Enfermedad
KW  - Haplotipos
KW  - Fenotipo
KW  - Inmunidad Adaptativa
KW  - Antibacterianos
KW  - Genes Clase I del Complejo de Histocompatibilidad (MHC)
KW  - Genes Clase II del Complejo de Histocompatibilidad (MHC)
KW  - Antígenos HLA-A
KW  - Antígenos HLA-DQ
KW  - Antígenos HLA-DR
KW  - Cadenas beta de HLA-DR
KW  - Factores de Riesgo
KW  - España
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Penicillin G::Ampicillin::Amoxicillin::Amoxicillin-Potassium Clavulanate Combination
KW  - Medical Subject Headings::Diseases::Substance-Related Disorders::Poisoning::Drug-Induced Liver Injury
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Disease
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Haplotypes
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
KW  - Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class I
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Major Histocompatibility Complex::Genes, MHC Class II
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class I::HLA-A Antigens
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DQ Antigens
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
KW  - Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
TI  - HLA Alleles Influence the Clinical Signature of Amoxicillin-Clavulanate Hepatotoxicity.
TY  - research article
ER  -