TY - JOUR AU - Rubio-Navarro, Alfonso AU - Vazquez-Carballo, Cristina AU - Guerrero-Hue, Melania AU - Garcia-Caballero, Cristina AU - Herencia, Carmen AU - Gutierrez, Eduardo AU - Yuste, Claudia AU - Sevillano, Angel AU - Praga, Manuel AU - Egea, Javier AU - Cannata, Pablo AU - Cortegano, Isabel AU - de Andres, Belen AU - Gaspar, Maria Luisa AU - Cadenas, Susana AU - Michalska, Patrycja AU - Leon, Rafael AU - Ortiz, Alberto AU - Egido, Jesus AU - Moreno, Juan Antonio PY - 2019 DO - 10.3389/fphar.2019.00740 SN - 1663-9812 UR - http://hdl.handle.net/10668/14287 T2 - Frontiers in pharmacology AB - Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins. We... LA - en KW - Nrf2 KW - Heme KW - Hemoglobin KW - Intravascular hemolysis KW - Oxidative stress KW - Sulforaphane KW - Tubular injury KW - Antioxidants KW - Hemolysis KW - Lipocalin-2 KW - Heme oxygenase-1 KW - Ferritins KW - Injections, intraperitoneal KW - Kidney KW - Acute kidney injury KW - Hemoglobins KW - Oxidative stress TI - Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury. TY - research article VL - 10 ER -