RT Journal Article T1 Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study. A1 Linares-Pineda, Teresa Maria A1 Boughanem, Hatim A1 Gutierrez-Repiso, Carolina A1 Macias-Gonzalez, Manuel A1 Andres-Leon, Eduardo A1 Rojo-Martinez, Gemma A1 Valdes, Sergio A1 Tinahones, Francisco J A1 Morcillo, Sonsoles K1 Insulin Resistance K1 Obesity, Metabolically Benign K1 Diabetes Mellitus, Type 2 K1 Cardiovascular Diseases K1 Global Health AB Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. Accordingly, long- term obesity is involved in an increased risk of developing several metabolic diseases, such as cardiovascular diseases, insulin resistance or type 2 diabetes. Although it is common to find obesity- related disorders in the majority of individuals with obesity, some of them do not show metabolic complications.1 Obese people without these metabolic disorders are defined as metabolically healthy obesity (MHO) individuals, whereas those who present metabolic complications are known as metabolically unhealthy obesity (MUO) subjects. PB John Wiley & Sons YR 2022 FD 2022-07-12 LK http://hdl.handle.net/10668/19947 UL http://hdl.handle.net/10668/19947 LA en NO Linares-Pineda TM, Boughanem H, Gutiérrez-Repiso C, Macías-González M, Andrés-León E, Rojo-Martínez G, et al. Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study. Eur J Clin Invest. 2022 Aug;52(8):e13783 DS RISalud RD Jun 1, 2025