RT Journal Article
T1 Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment?
A1 Lopez, Miguel
A1 Tena-Sempere, Manuel
K1 Energy expenditure
K1 Estrogens
K1 Food intake
K1 Hypothalamus
K1 Metabolism
K1 Obesity
AB In addition to their prominent roles in the control of reproduction, estrogens are important modulators of energy balance, as evident in conditions of deficiency of estrogens, which are characterized by increased feeding and decreased energy expenditure, leading to obesity. AMP-activated protein kinase (AMPK) is a ubiquitous cellular energy gauge that is activated under conditions of low energy, increasing energy production and reducing energy wasting. Centrally, the AMPK pathway is a canonical route regulating energy homeostasis, by integrating peripheral signals, such as hormones and metabolites, with neuronal networks. As a result of those actions, hypothalamic AMPK modulates feeding, as well as brown adipose tissue (BAT) thermogenesis and browning of white adipose tissue (WAT). Here, we will review the central actions of estrogens on energy balance, with particular focus on hypothalamic AMPK. The relevance of this interaction is noteworthy, because some agents with known actions on metabolic homeostasis, such as nicotine, metformin, liraglutide, olanzapine and also natural molecules, such as resveratrol and flavonoids, exert their actions by modulating AMPK. This evidence highlights the possibility that hypothalamic AMPK might be a potential target for the treatment of obesity.
PB Elsevier
YR 2017
FD 2017-03-27
LK http://hdl.handle.net/10668/11018
UL http://hdl.handle.net/10668/11018
LA en
NO López M, Tena-Sempere M. Estradiol effects on hypothalamic AMPK and BAT thermogenesis: A gateway for obesity treatment? Pharmacol Ther. 2017 Oct;178:109-122
NO The research leading to these results has received funding from theEuropean Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 281854 - the ObERStress European Re search Council project (ML), Xunta de Galicia (ML: 2015-CP079 and2016-PG068), Junta de Andalucía (MTS: P08-CVI-03788 and P12-FQM-01943), MINECO co-funded by the FEDER Program of EU (ML:SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast; MTS:BFU2011-25021 and BFU2014-58571-P) and ISCIII (MTS: PIE2014-005). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiativeof ISCIII.
DS RISalud
RD Apr 10, 2025