RT Journal Article
T1 Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results.
A1 Palomo-López, Nora
A1 Rodríguez-Rodríguez, Ana
A1 Martín-Villén, Luis
A1 Mendoza-Prieto, María
A1 Ruiz de Azúa-López, Zaida
A1 Sempere-Bordes, Lluis
A1 Boyero-Corral, Laura
A1 Daga-Ruiz, Domingo
A1 Gordillo-Brenes, Antonio
A1 Pacheco-Sánchez, María
A1 Perez-Villares, José Miguel
A1 Vilches-Arenas, Ángel
A1 Egea-Guerrero, Juan José
K1 antioxidant effect
K1 brain death donor
K1 donation after circulatory death
K1 ischemia
K1 malondialdehyde
K1 melatonin
K1 oxidative stress
AB The objective was to quantify oxidative stress resulting from ischemia during the donation process, using malondialdehyde (MDA) measurement, and its modulation by the administration of melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo. We collected donors by donation after brain death (DBD) and controlled donation after circulatory death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic variables and medical history were collected. We also collected serial measurements of MDA, at 60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE were similar between groups. Although MDA values did not differ in the DBD group, statistical differences were observed in DCD donors during the 0-60 min interval: -4.296 (-6.752; -2.336) in the melatonin group and -1.612 (-2.886; -0.7445) in controls. Given the antioxidant effect of melatonin, its use could reduce the production of oxidative stress in controlled DCD.
SN 2227-9032
YR 2022
FD 2022-04-20
LK http://hdl.handle.net/10668/20993
UL http://hdl.handle.net/10668/20993
LA en
DS RISalud
RD Apr 18, 2025