RT Journal Article
T1 Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications.
A1 Bullón-Vela, Vanessa
A1 Abete, Itziar
A1 Tur, Josep A
A1 Konieczna, Jadwiga
A1 Romaguera, Dora
A1 Pintó, Xavier
A1 Corbella, Emili
A1 Martínez-González, Miguel A
A1 Sayón-Orea, Carmen
A1 Toledo, Estefanía
A1 Corella, Dolores
A1 Macías-Gonzalez, Manuel
A1 Tinahones, Francisco J
A1 Fitó, Montserrat
A1 Estruch, Ramon
A1 Ros, Emilio
A1 Salas-Salvadó, Jordi
A1 Daimiel, Lidia
A1 Mascaró, Catalina M
A1 Zulet, Maria Angeles
A1 Martínez, José Alfredo
K1 insulin resistance
K1 metabolic syndrome
K1 non-alcoholic fatty liver disease
K1 triglyceride glucose index
K1 visceral adipose tissue
AB Visceral adipose tissue (VAT) has a hazardous influence on systemic inflammation, insulin resistance and an adverse metabolic profile, which increases the risk of developing non-alcoholic fatty liver disease (NAFLD) and chronic complications of diabetes. In our study we aimed to evaluate the association of VAT and the triglyceride glucose (TyG) as a proxy of insulin resistance surrogated with metabolic and liver risk factors among subjects diagnosed with metabolic syndrome (MetS). A cross-sectional study was performed including 326 participants with MetS (55-75 years) from the PREDIMED-Plus study. Liver-status markers, VAT and TyG were assessed. Participants were stratified by tertiles according to VAT (n = 254) and TyG (n = 326). A receiver operating characteristic curve was used to analyse the efficiency of TyG for VAT. Subjects with greater visceral fat depots showed worse lipid profile, higher homeostatic model assessment for insulin resistance (HOMA-IR), TyG, alanine transaminase (ALT), fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared with participants in the first tertile. The multi-adjusted linear-regression analyses indicated that individuals in the third tertile of TyG (>9.1-10.7) had a positive association with HOMA-IR [β = 3.07 (95% confidence interval (CI) 2.28-3.86; p trend 9.1-10.7) had a positive association with HOMA-IR [β = 3.07 (95% confidence interval (CI) 2.28-3.86; p trend  A disrupted VAT enlargement and impairment of TyG are strongly associated with liver status and cardiometabolic risk factors linked with NAFLD in individuals diagnosed with MetS. Moreover, the TyG could be used as a suitable and reliable marker estimator of VAT.
SN 2042-0188
YR 2020
FD 2020-10-23
LK https://hdl.handle.net/10668/26970
UL https://hdl.handle.net/10668/26970
LA en
DS RISalud
RD Apr 17, 2025