RT Journal Article
T1 Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: the al-Andalus project
A1 Estevez-Lopez, Fernando
A1 Guerrero-Gonzalez, Juan M.
A1 Salazar-Tortosa, Diego
A1 Camiletti-Moiron, Daniel
A1 Gavilan-Carrera, Blanca
A1 Aparicio, Virginia A.
A1 Acosta-Manzano, Pedro
A1 Alvarez-Gallardo, Inmaculada C.
A1 Segura-Jimenez, Victor
A1 Soriano-Maldonado, Alberto
A1 Geenen, Rinie
A1 Delgado-Fernandez, Manuel
A1 Martinez-Gonzalez, Luis J.
A1 Ruiz, Jonatan R.
A1 Alvarez-Cubero, Maria J.
K1 adrenoceptor alpha 1A gene
K1 charged multivesicular body protein 1A gene
K1 5-hydroxytryptamine receptor 2A gene
K1 opioid receptor mu 1 gene
K1 sodium voltage-gated channel alpha subunit 9 gene
K1 Physical-activity
K1 Healthy controls
K1 Polymorphisms
K1 Sensitivity
K1 Genes
K1 Association
K1 Severity
K1 Symptoms
K1 Genotype
K1 Receptor
AB Objectives It is widely acknowledged that the experience of pain is promoted by both genetic susceptibility and environmental factors such as engaging in physical activity (PA), and that pain-related cognitions are also important. Thus, the purpose of the present study was to test the association of 64 polymorphisms (34 candidate genes) and the gene-gene, gene-PA and gene-sedentary behaviour interactions with pain and pain-related cognitions in women with FM.Methods Saliva samples from 274 women with FM [mean (S.D.) age 51.7 (7.7) years] were collected for extracting DNA. We measured PA and sedentary behaviour by accelerometers for a week, pain with algometry and questionnaires, and pain-related cognitions with questionnaires. To assess the robustness of the results, a meta-analysis was also performed.Results The rs6311 and rs6313 polymorphisms (5-hydroxytryptamine receptor 2A, HTR2A) were individually related to algometer scores. The interaction of rs4818 (catechol-O-methyltransferase, COMT) and rs1799971 (opioid receptor mu gene, OPRM1) was related to pain catastrophizing. Five gene-behaviour interactions were significant: the interactions of sedentary behaviour with rs1383914 (adrenoceptor alpha 1A, ADRA1A), rs6860 (charged multivesicular body protein 1A, CHMP1A), rs4680 (COMT), rs165599 (COMT) and rs12994338 (SCN9A) on bodily pain subscale of the Short Form 36. Furthermore, the meta-analysis showed an association between rs4680 (COMT) and severity of FM symptoms (codominant model, P-value 0.032).Conclusion The HTR2A gene (individually), COMT and OPRM1 gene-gene interaction, and the interactions of sedentary behaviour with ADRA1A, CHMP1A, COMT and SCN9A genes were associated with pain-related outcomes. Collectively, findings from the present study indicate a modest contribution of genetics and gene-sedentary behaviour interaction to pain and pain catastrophizing in women with FM. Future research should examine whether reducing sedentary behaviour is particularly beneficial for reducing pain in women with genetic susceptibility to pain.
PB Oxford univ press
SN 1462-0324
YR 2022
FD 2022-03-11
LK https://hdl.handle.net/10668/26376
UL https://hdl.handle.net/10668/26376
LA en
DS RISalud
RD Apr 10, 2025