RT Journal Article
T1 Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia.
A1 Zapata-Arriaza, Elena
A1 Mancha, Fernando
A1 Bustamante, Alejandro
A1 Moniche, Francisco
A1 Pardo-Galiana, Blanca
A1 Serrano-Gotarredona, Pilar
A1 Navarro-Herrero, Silvia
A1 Pallisa, Esther
A1 Faura, Julia
A1 Vega-Salvatierra, Angela
A1 Penalba, Anna
A1 Escudero-Martinez, Irene
A1 Ramos-Herrero, Víctor Dario
A1 Azurmendi, Leire
A1 Sanchez, Jean Charles
A1 Montaner, Joan
K1 Adrenomedullin
K1 Biomarkers
K1 Humans
K1 Pneumonia
K1 Receptors, Urokinase Plasminogen Activator
AB To confirm the diagnostic accuracy of candidate biomarkers in stroke-associated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR-proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evaluated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies.
PB John Wiley & Sons Ltd.
YR 2019
FD 2019-07-31
LK http://hdl.handle.net/10668/14345
UL http://hdl.handle.net/10668/14345
LA en
NO Zapata-Arriaza E, Mancha F, Bustamante A, Moniche F, Pardo-Galiana B, Serrano-Gotarredona P, et al. Biomarkers predictive value for early diagnosis of Stroke-Associated Pneumonia. Ann Clin Transl Neurol. 2019 Sep;6(9):1882-1887.
DS RISalud
RD Apr 7, 2025