RT Journal Article
T1 Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review.
A1 Garcia-Foncillas, J
A1 Alba, E
A1 Aranda, E
A1 Diaz-Rubio, E
A1 Lopez-Lopez, R
A1 Tabernero, J
A1 Vivancos, A
K1 EGFR
K1 Colorectal cancer
K1 Liquid biopsy
K1 Mutation testing
K1 Tumor resistance
AB The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. The detection of mutated circulating tumor DNA by BEAMing technology addresses this gap in care and allows these patients to receive international guideline-recommended expanded RAS testing with rapid turnaround times. Furthermore, the overall concordance between OncoBEAM RAS colorectal cancer testing and standard of care tissue testing is very high (93.3%). This article presents an overview of the clinical utility and potential applications of this minimally invasive method, such as early detection of emergent resistance to anti-epidermal growth factor receptor therapy. If appropriately implemented, BEAMing technology holds considerable promise to enhance the quality of patient care and improve clinical outcomes.
PB Elsevier
YR 2017
FD 2017
LK http://hdl.handle.net/10668/11607
UL http://hdl.handle.net/10668/11607
LA en
NO García-Foncillas J, Alba E, Aranda E, Díaz-Rubio E, López-López R, Tabernero J, et al. Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients: an expert taskforce review. Ann Oncol. 2017 Dec 1;28(12):2943-2949
DS RISalud
RD Aug 21, 2025