TY  - JOUR
AU  - Egg, David
AU  - Schwab, Charlotte
AU  - Gabrysch, Annemarie
AU  - Arkwright, Peter D
AU  - Cheesman, Edmund
AU  - Giulino-Roth, Lisa
AU  - Neth, Olaf
AU  - Snapper, Scott
AU  - Okada, Satoshi
AU  - Moutschen, Michel
AU  - Delvenne, Philippe
AU  - Pecher, Ann-Christin
AU  - Wolff, Daniel
AU  - Kim, Yae-Jean
AU  - Seneviratne, Suranjith
AU  - Kim, Kyoung-Mee
AU  - Kang, Ji-Man
AU  - Ojaimi, Samar
AU  - McLean, Catriona
AU  - Warnatz, Klaus
AU  - Seidl, Maximilian
AU  - Grimbacher, Bodo
PY  - 2018
DO  - 10.3389/fimmu.2018.02012
UR  - http://hdl.handle.net/10668/12992
T2  - Frontiers in immunology
AB  - Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a negative immune regulator on the surface of T cells. In humans, heterozygous germline mutations in CTLA4 can cause an immune dysregulation syndrome. The phenotype comprises a broad...
LA  - en
KW  - CMV
KW  - CTLA4
KW  - EBV
KW  - cancer predisposition
KW  - combined immunodeficiency
KW  - malignancy
KW  - primary immunodeficiency
KW  - Adenocarcinoma
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - CTLA-4 Antigen
KW  - Cohort Studies
KW  - Epstein-Barr Virus Infections
KW  - Female
KW  - Herpesvirus 4, Human
KW  - Humans
KW  - Lymphoma
KW  - Male
KW  - Middle Aged
KW  - Mutation
KW  - Prevalence
KW  - Risk
KW  - Stomach Neoplasms
KW  - Young Adult
TI  - Increased Risk for Malignancies in 131 Affected CTLA4 Mutation Carriers.
TY  - research article
VL  - 9
ER  -