RT Journal Article
T1 Aberrant Claustrum Microstructure in Humans after Premature Birth
A1 Hedderich, Dennis M.
A1 Menegaux, Aurore
A1 Li, Hongwei
A1 Schmitz-Koep, Benita
A1 Staempfli, Philipp
A1 Baeuml, Josef G.
A1 Berndt, Maria T.
A1 Baeuerlein, Felix J. B.
A1 Grothe, Michel J.
A1 Dyrba, Martin
A1 Avram, Mihai
A1 Boecker, Henning
A1 Daamen, Marcel
A1 Zimmer, Claus
A1 Bartmann, Peter
A1 Wolke, Dieter
A1 Sorg, Christian
K1 claustrum
K1 cognitive difficulties
K1 magnetic resonance imaging
K1 mean diffusivity
K1 premature birth
K1 subplate neurons
K1 Transient subplate zone
K1 Diffusion tensor
K1 Preterm birth
K1 White-matter
K1 Brain-injury
K1 Gestational-age
K1 Neurons
K1 Cortex
K1 Organization
K1 Expression
AB Several observations suggest an impact of prematurity on the claustrum. First, the claustrum's development appears to depend on transient subplate neurons of intra-uterine brain development, which are affected by prematurity. Second, the claustrum is the most densely connected region of the mammalian forebrain relative to its volume; due to its effect on pre-oligodendrocytes, prematurity impacts white matter connections and thereby the development of sources and targets of such connections, potentially including the claustrum. Third, due to its high connection degree, the claustrum contributes to general cognitive functioning (e.g., selective attention and task switching/maintaining); general cognitive functioning, however, is at risk in prematurity. Thus, we hypothesized altered claustrum structure after premature birth, with these alterations being associated with impaired general cognitive performance in premature born persons. Using T1-weighted and diffusion-weighted magnetic resonance imaging in 70 very preterm/very low-birth-weight (VP/VLBW) born adults and 87 term-born adults, we found specifically increased mean diffusivity in the claustrum of VP/VLBW adults, associated both with low birth weight and at-trend with reduced IQ. This result demonstrates altered claustrum microstructure after premature birth. Data suggest aberrant claustrum development, which is potentially related with aberrant subplate neuron and forebrain connection development of prematurity.
PB Oxford univ press inc
SN 1047-3211
YR 2021
FD 2021-06-25
LK https://hdl.handle.net/10668/27928
UL https://hdl.handle.net/10668/27928
LA en
NO Hedderich DM, Menegaux A, Li H, Schmitz-Koep B, Stämpfli P, Bäuml JG, et al. Aberrant Claustrum Microstructure in Humans after Premature Birth. Cereb Cortex. 2021 Oct 22;31(12):5549-5559.
DS RISalud
RD Apr 5, 2025