RT Journal Article
T1 Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery
A1 Micó-Carnero, Marc
A1 Rojano-Alfonso, Carlos
A1 Álvarez-Mercado, Ana Isabel
A1 Gracia-Sancho, Jordi
A1 Casillas-Ramírez, Araní
A1 Peralta, Carmen
K1 Microbiota
K1 Liver transplantation
K1 Partial hepatectomy
K1 Liver surgery
K1 Ischemia-reperfusion
K1 Trasplante de hígado
K1 Hepatectomía
K1 Cirugía general
K1 Higado
K1 Daño por reperfusión
AB Microbiota is defined as the collection of microorganisms within the gastrointestinal ecosystem. These microbes are strongly implicated in the stimulation of immune responses. An unbalanced microbiota, termed dysbiosis, is related to the development of several liver diseases. The bidirectional relationship between the gut, its microbiota and the liver is referred to as the gut-liver axis. The translocation of bacterial products from the intestine to the liver induces inflammation in different cell types such as Kupffer cells, and a fibrotic response in hepatic stellate cells, resulting in deleterious effects on hepatocytes. Moreover, ischemia-reperfusion injury, a consequence of liver surgery, alters the microbiota profile, affecting inflammation, the immune response and even liver regeneration. Microbiota also seems to play an important role in post-operative outcomes (i.e., liver transplantation or liver resection). Nonetheless, studies to determine changes in the gut microbial populations produced during and after surgery, and affecting liver function and regeneration are scarce. In the present review we analyze and discuss the preclinical and clinical studies reported in the literature focused on the evaluation of alterations in microbiota and its products as well as their effects on post-operative outcomes in hepatic surgery.
PB MDPI
SN 1661-6596
YR 2020
FD 2020-12-22
LK http://hdl.handle.net/10668/4563
UL http://hdl.handle.net/10668/4563
LA en
NO Micó-Carnero M, Rojano-Alfonso C, Álvarez-Mercado AI, Gracia-Sancho J, Casillas-Ramírez A, Peralta C. Effects of Gut Metabolites and Microbiota in Healthy and Marginal Livers Submitted to Surgery. Int J Mol Sci. 2020 Dec 22;22(1):44
DS RISalud
RD Apr 7, 2025