RT Journal Article
T1 Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research.
A1 Sobrino, Veronica
A1 Avendaño, Maria Soledad
A1 Perdices-Lopez, Cecilia
A1 Jimenez-Puyer, Manuel
A1 Tena-Sempere, Manuel
K1 GnRH
K1 Gpr54
K1 Kiss1
K1 Kisspeptins
K1 Nutrition
K1 Obesity
K1 Puberty
K1 Reproduction
AB In late 2003, a major breakthrough in our understanding of the mechanisms that govern reproduction occurred with the identification of the reproductive roles of kisspeptins, encoded by the Kiss1 gene, and their receptor, Gpr54 (aka, Kiss1R). The discovery of this unsuspected reproductive facet attracted an extraordinary interest and boosted an intense research activity, in human and model species, that, in a relatively short period, established a series of basic concepts on the physiological roles of kisspeptins. Such fundamental knowledge, gathered in these early years of kisspeptin research, set the scene for the more recent in-depth dissection of the intimacies of the neuronal networks involving Kiss1 neurons, their precise mechanisms of regulation and the molecular underpinnings of the function of kisspeptins as pivotal regulators of all key aspects of reproductive function, from puberty onset to pulsatile gonadotropin secretion and the metabolic control of fertility. While no clear temporal boundaries between these two periods can be defined, in this review we will summarize the most prominent advances in kisspeptin research occurred in the last ten years, as a means to provide an up-dated view of the state of the art and potential paths of future progress in this dynamic, and ever growing domain of Neuroendocrinology.
PB Elsevier
YR 2021
FD 2021-12-22
LK http://hdl.handle.net/10668/22546
UL http://hdl.handle.net/10668/22546
LA en
NO Sobrino V, Avendaño MS, Perdices-López C, Jimenez-Puyer M, Tena-Sempere M. Kisspeptins and the neuroendocrine control of reproduction: Recent progress and new frontiers in kisspeptin research. Front Neuroendocrinol. 2022 Apr;65:100977
NO The authors are indebted with the members of their research team at the Physiology Section of the University of Cordoba and IMIBIC, who actively participated in the generation of some experimental data dis cussed herein. The work from the authors’ laboratory summarized in this article was supported by grants BFU2017-83934-P and PID2020-118660GB-I00 (Agencia Estatal de Investigacion, ´ Spain; co-funded with EU funds from FEDER Program); project PIE14-00005 (Flexi-Met, Instituto de Salud Carlos III, Ministerio de Sanidad, Spain); Projects P12-FQM-01943 and P18-RT-4093 (Junta de Andalucía, Spain); and EU research contract GAP-2014-655232. CIBER is an initiative of Instituto de Salud Carlos III (Ministerio de Sanidad, Spain).
DS RISalud
RD Apr 9, 2025