TY - JOUR AU - Garcia-Alfonso, Pilar AU - Benavides, Manuel AU - Falco, Esther AU - Muñoz, Andres AU - Gomez, Auxiliadora AU - Sastre, Javier AU - Rivera, Fernando AU - Montagut, Clara AU - Salgado, Mercedes AU - Lopez-Ladron, Amelia AU - Lopez, Rafael AU - Ruiz de Mena, Inmaculada AU - Duran, Gema AU - Aranda, Enrique PY - 2018 DO - 10.1634/theoncologist.2018-0316 UR - http://hdl.handle.net/10668/12849 T2 - The oncologist AB - RAS- or BRAF-mutated metastatic colorectal cancers (mCRCs) progressing after first-line treatment have a poor prognosis.European and U.S. guidelines include the multikinase inhibitor regorafenib as a standard option for second-line therapy and beyond,... LA - en PB - Oxford University Press KW - Área de Gestión Sanitaria Sur de Sevilla KW - Antineoplastic agents, immunological KW - Antineoplastic combined chemotherapy protocols KW - Bevacizumab KW - Camptothecin KW - Colorectal neoplasms KW - Female KW - Fluorouracil KW - Humans KW - Leucovorin KW - Male KW - Mutation KW - Neoplasm metastasis KW - Organoplatinum compounds KW - Phenylurea compounds KW - Proto-oncogene proteins B-raf KW - Pyridines KW - ras proteins TI - Single-Agent Regorafenib in Metastatic Colorectal Cancer Patients with Any RAS or BRAF Mutation Previously Treated with FOLFOXIRI plus Bevacizumab (PREVIUM Trial). TY - research article VL - 23 ER -