RT Journal Article T1 The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth. A1 Giorgis-Allemand, Lise A1 Pedersen, Marie A1 Bernard, Claire A1 Aguilera, Inmaculada A1 Beelen, Rob M J A1 Chatzi, Leda A1 Cirach, Marta A1 Danileviciute, Asta A1 Dedele, Audrius A1 van Eijsden, Manon A1 Estarlich, Marisa A1 Fernández-Somoano, Ana A1 Fernández, Mariana F A1 Forastiere, Francesco A1 Gehring, Ulrike A1 Grazuleviciene, Regina A1 Gruzieva, Olena A1 Heude, Barbara A1 Hoek, Gerard A1 de Hoogh, Kees A1 van den Hooven, Edith H A1 Håberg, Siri E A1 Iñiguez, Carmen A1 Jaddoe, Vincent W V A1 Korek, Michal A1 Lertxundi, Aitana A1 Lepeule, Johanna A1 Nafstad, Per A1 Nystad, Wenche A1 Patelarou, Evridiki A1 Porta, Daniela A1 Postma, Dirkje A1 Raaschou-Nielsen, Ole A1 Rudnai, Peter A1 Siroux, Valérie A1 Sunyer, Jordi A1 Stephanou, Euripides A1 Sørensen, Mette A1 Eriksen, Kirsten Thorup A1 Tuffnell, Derek A1 Varró, Mihály J A1 Vrijkotte, Tanja G M A1 Wijga, Alet A1 Wright, John A1 Nieuwenhuijsen, Mark J A1 Pershagen, Göran A1 Brunekreef, Bert A1 Kogevinas, Manolis A1 Slama, Rémy K1 atmospheric pollution K1 atmospheric pressure K1 cohort studies K1 humidity K1 meteorological conditions K1 pooled analysis K1 preterm birth K1 temperature AB Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994-2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. Atmospheric pollution measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the -5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure. YR 2017 FD 2017 LK http://hdl.handle.net/10668/10772 UL http://hdl.handle.net/10668/10772 LA en DS RISalud RD Apr 4, 2025