RT Journal Article
T1 Non-oncotic properties of albumin. A multidisciplinary vision about the implications for critically ill patients.
A1 Ferrer, Ricard
A1 Mateu, Xavier
A1 Maseda, Emilio
A1 Yébenes, Juan Carlos
A1 Aldecoa, César
A1 De Haro, Candelaria
A1 Ruiz-Rodriguez, Juan Carlos
A1 Garnacho-Montero, José
K1 Albumin
K1 antioxidation
K1 critical care
K1 drug transportation
K1 endothelium
K1 immunomodulation
K1 sepsis
AB Effective resuscitation with human albumin solutions is achieved with less fluid than with crystalloid solutions. However, the role of albumin in today's critical care unit is also linked to its multiple pharmacological effects. Areas covered: The potential clinical benefits of albumin in select populations of critically ill patients like sepsis seem related to immunomodulatory and anti-inflammatory effects, antibiotic transportation and endothelial stabilization. Albumin transports many drugs used in critically ill patients. Such binding to albumin is frequently lessened in critically ill patients with hypoalbuminemia. These changes could result in sub-optimal treatment. Albumin has immunomodulatory capacity by binding several bacterial products. Albumin also influences vascular integrity, contributing to the maintenance of the normal capillary permeability. Moreover, the albumin molecule encompasses several antioxidant properties, thereby significantly reducing re-oxygenation injury, which is especially important in sepsis. In fact, most studies of albumin administration are a combination of a degree of resuscitation with a degree of maintenance or supplementation of albumin. Expert commentary: The potential clinical benefits of the use of albumin in selected critically ill patients such as sepsis seem related to its immunomodulatory and anti-inflammatory effects, antioxidant properties, antibiotic transportation and endothelial stabilization. Additional studies are warranted to further elucidate the underlying physiologic and molecular rationale.
YR 2017
FD 2017-12-08
LK http://hdl.handle.net/10668/11888
UL http://hdl.handle.net/10668/11888
LA en
DS RISalud
RD Apr 6, 2025