RT Journal Article
T1 Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity.
A1 Oses, Maddi
A1 Cadenas-Sanchez, Cristina
A1 Medrano, Maria
A1 Galbete, Arkaitz
A1 Miranda-Ferrua, Emiliano
A1 Ruiz, Jonatan R
A1 Sanchez-Valverde, Felix
A1 Ortega, Francisco B
A1 Cabeza, Rafael
A1 Villanueva, Arantxa
A1 Idoate, Fernando
A1 Labayen, Idoia
K1 Paediatric obesity
K1 fatty liver
K1 metabolic diseases
K1 primary health care
AB The early detection and management of children with metabolic associated fatty liver disease (MAFLD) is challenging. To develop a non-invasive and accurate prediction protocol for the identification of MAFLD among children with overweight/obesity candidates to confirmatory diagnosis. A total of 115 children aged 8-12 years with overweight/obesity, recruited at a primary care, were enrolled in this cross-sectional study. The external validation was performed using a cohort of children with overweight/obesity (N = 46) aged 8.5-14.0 years. MAFLD (≥5.5% hepatic fat) was diagnosed by magnetic resonance imaging (MRI). Fasting blood biochemical parameters were measured, and 25 candidates' single nucleotide polymorphisms (SNPs) were determined. Variables potentially associated with the presence of MAFLD were included in a multivariate logistic regression. Children with MAFLD (36%) showed higher plasma triglycerides (TG), insulin, homeostasis model assessment of insulin resistance (HOMA-IR), alanine aminotransferase (ALT), aspartate transaminase (AST), glutamyl-transferase (GGT) and ferritin (p  The HEPAKID prediction protocol is an accurate, easy to implant, minimally invasive and low economic cost tool useful for the early identification and management of paediatric MAFLD in primary care.
PB Wiley-Blackwell Publishing Ltd.
YR 2022
FD 2022-03-07
LK http://hdl.handle.net/10668/19969
UL http://hdl.handle.net/10668/19969
LA en
NO Oses M, Cadenas-Sanchez C, Medrano M, Galbete A, Miranda-Ferrua E, Ruiz JR, et al.  Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity. Pediatr Obes. 2022 Sep;17(9):e12917.
NO This project was funded by the Spanish Ministry of Health ‘Fondos de Investigación Sanitaria del Instituto de Salud Carlos III’ (PI13/01335), the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), by EU Fondos Estructurales de la Unión Europea (FEDER) funds (‘Una manera de hacer Europa’) and Department of Economic Development of Government of Navarra (0011-1365-2019-000000, 0011-1365-2020-00140). M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number; BES-2017-080770. We thank Open Access funding provided by Universidad Pública de Navarra. A special thank for the families, both children and parents, for their participation and collaboration in the study.
DS RISalud
RD Apr 12, 2025