RT Journal Article
T1 Circadian Genes as Therapeutic Targets in Pancreatic Cancer
A1 García-Costela, María
A1 Escudero-Feliú, Julia
A1 Puentes-Pardo, Jose D.
A1 San Juán, Sara Moreno
A1 Morales-Santana, Sonia
A1 Ríos-Arrabal, Sandra
A1 Carazo, Ángel
A1 León, Josefa
K1 Pancreatic cancer
K1 Circadian clock
K1 Chemotherapy
K1 Metabolism
K1 Precision medicine
K1 Neoplasias pancreáticas
K1 Relojes circadianos
K1 Drug therapy
K1 Metabolismo
K1 Medicina de precisión
AB Pancreatic cancer is one of the most lethal cancers worldwide due to its symptoms, early metastasis, and chemoresistance. Thus, the mechanisms contributing to pancreatic cancer progression require further exploration. Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. Several evidences suggest that the circadian clock may play an important role in the cell cycle, cell proliferation and apoptosis. In addition, timing of chemotherapy or radiation treatment can influence the efficacy and toxicity treatment. Here, we revisit the studies on circadian clock as an emerging target for therapy in pancreatic cancer. We highlight those potential circadian genes regulators that are commonly affected in pancreatic cancer according to most recent reports.
PB Frontiers
YR 2020
FD 2020-09-11
LK http://hdl.handle.net/10668/3502
UL http://hdl.handle.net/10668/3502
LA en
NO García-Costela M, Escudero-Feliú J, Puentes-Pardo JD, San Juán SM, Morales-Santana S, Ríos-Arrabal S, et al. Circadian Genes as Therapeutic Targets in Pancreatic Cancer. Front Endocrinol (Lausanne). 2020 Sep 11;11:638
DS RISalud
RD Apr 8, 2025