RT Journal Article
T1 Accumulation of scandium in plasma in patients with chronic renal failure.
A1 Sánchez-González, Cristina
A1 López-Chaves, Carlos
A1 Rivas-García, Lorenzo
A1 Galindo, Pilar
A1 Gómez-Aracena, Jorge
A1 Aranda, Pilar
A1 Llopis, Juan
K1 Escandio
K1 Adulto
K1 Factores de Edad
K1 Índice de Masa Corporal
K1 Creatinina
K1 Estudios Transversales
K1 Progresión de la Enfermedad
K1 Índices de Eritrocitos
K1 Tasa de Filtración Glomerular
K1 Humanos
K1 Femenino
K1 Masculino
K1 Fallo Renal Crónico
K1 Mediana Edad
K1 Uremia
K1 Adulto Joven
K1 Adolescente
AB Scandium (Sc) is an element with many industrial applications, but relatively little is known about its physiological and/or toxicological effects, and very little data are available concerning the role of Sc in chronic renal failure (CRF). This paper examines the changes in plasma levels of Sc in predialysis patients with CRF and the relationship with blood parameters. The participants in this trial were 48 patients with CRF in predialysis and 53 healthy controls. Erythrocyte, haemoglobin, and haematocrit counts in blood were determined, and levels of creatinine, urea, uric acid, albumin, total protein and Sc were measured in plasma. The glomerular filtration rate (GFR) was calculated using the Cockcroft-Gault index. The CRF patients were found to have higher plasma levels of creatinine, urea, uric acid, albumin, total protein, and Sc and a lower GFR than that the controls. Scandium in plasma was positively correlated with creatinine and plasma urea and negatively correlated with GFR, haemoglobin, and haematocrit and was associated with the risk of lower levels of erythrocytes, haemoglobin, and haematocrit. CRF was associated with increases in the circulating levels of scandium.
PB Hindawi Publishing Corporation
YR 2013
FD 2013-12-12
LK http://hdl.handle.net/10668/1700
UL http://hdl.handle.net/10668/1700
LA en
NO Sánchez-González C, López-Chaves C, Rivas-García L, Galindo P, Gómez-Aracena J, Aranda P, et al. Accumulation of scandium in plasma in patients with chronic renal failure. ScientificWorldJournal; 2013:782745
NO Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 9, 2025