RT Journal Article
T1 Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.
A1 Salazar de Pablo, Gonzalo
A1 Guinart, Daniel
A1 Cornblatt, Barbara A
A1 Auther, Andrea M
A1 Carrión, Ricardo E
A1 Carbon, Maren
A1 Jiménez-Fernández, Sara
A1 Vernal, Ditte L
A1 Walitza, Susanne
A1 Gerstenberg, Miriam
A1 Saba, Riccardo
A1 Lo Cascio, Nella
A1 Brandizzi, Martina
A1 Arango, Celso
A1 Moreno, Carmen
A1 Van Meter, Anna
A1 Correll, Christoph U
K1 adolescence
K1 bipolar disorder
K1 prevention
K1 risk
K1 subsyndromal
AB Objectives: Bipolar disorder (BD) is a debilitating illness that often starts at an early age. Prevention of first and subsequent mood episodes, which are usually preceded by a period characterized by subthreshold symptoms is important. We compared demographic and clinical characteristics including severity and duration of subsyndromal symptoms across adolescents with three different bipolar-spectrum disorders. Methods: Syndromal and subsyndromal psychopathology were assessed in adolescent inpatients (age = 12-18 years) with a clinical mood disorder diagnosis. Assessments included the validated Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P). We compared phenomenology across patients with a research consensus conference-confirmed DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) diagnoses of BD-I, BD-not otherwise specified (NOS), or mood disorder (MD) NOS. Results: Seventy-six adolescents (age = 15.6 ± 1.4 years, females = 59.2%) were included (BD-I = 24; BD-NOS = 29; MD-NOS = 23) in this study. Median baseline global assessment of functioning scale score was 21 (interquartile range = 17-40; between-group p = 0.31). Comorbidity was frequent, and similar across groups, including disruptive behavior disorders (55.5%, p = 0.27), anxiety disorders (40.8%, p = 0.98), and personality disorder traits (25.0%, p = 0.21). Mania symptoms (most frequent: irritability = 93.4%, p = 0.82) and depressive symptoms (most frequent: depressed mood = 81.6%, p = 0.14) were common in all three BD-spectrum groups. Manic and depressive symptoms were more severe in both BD-I and BD-NOS versus MD-NOS (p 
YR 2020
FD 2020-02-21
LK http://hdl.handle.net/10668/15142
UL http://hdl.handle.net/10668/15142
LA en
DS RISalud
RD Apr 5, 2025