%0 Journal Article
%A Salazar de Pablo, Gonzalo
%A Guinart, Daniel
%A Cornblatt, Barbara A
%A Auther, Andrea M
%A Carrión, Ricardo E
%A Carbon, Maren
%A Jiménez-Fernández, Sara
%A Vernal, Ditte L
%A Walitza, Susanne
%A Gerstenberg, Miriam
%A Saba, Riccardo
%A Lo Cascio, Nella
%A Brandizzi, Martina
%A Arango, Celso
%A Moreno, Carmen
%A Van Meter, Anna
%A Correll, Christoph U
%T Demographic and Clinical Characteristics, Including Subsyndromal Symptoms Across Bipolar-Spectrum Disorders in Adolescents.
%D 2020
%U http://hdl.handle.net/10668/15142
%X Objectives: Bipolar disorder (BD) is a debilitating illness that often starts at an early age. Prevention of first and subsequent mood episodes, which are usually preceded by a period characterized by subthreshold symptoms is important. We compared demographic and clinical characteristics including severity and duration of subsyndromal symptoms across adolescents with three different bipolar-spectrum disorders. Methods: Syndromal and subsyndromal psychopathology were assessed in adolescent inpatients (age = 12-18 years) with a clinical mood disorder diagnosis. Assessments included the validated Bipolar Prodrome Symptom Interview and Scale-Prospective (BPSS-P). We compared phenomenology across patients with a research consensus conference-confirmed DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) diagnoses of BD-I, BD-not otherwise specified (NOS), or mood disorder (MD) NOS. Results: Seventy-six adolescents (age = 15.6 ± 1.4 years, females = 59.2%) were included (BD-I = 24; BD-NOS = 29; MD-NOS = 23) in this study. Median baseline global assessment of functioning scale score was 21 (interquartile range = 17-40; between-group p = 0.31). Comorbidity was frequent, and similar across groups, including disruptive behavior disorders (55.5%, p = 0.27), anxiety disorders (40.8%, p = 0.98), and personality disorder traits (25.0%, p = 0.21). Mania symptoms (most frequent: irritability = 93.4%, p = 0.82) and depressive symptoms (most frequent: depressed mood = 81.6%, p = 0.14) were common in all three BD-spectrum groups. Manic and depressive symptoms were more severe in both BD-I and BD-NOS versus MD-NOS (p 
%K adolescence
%K bipolar disorder
%K prevention
%K risk
%K subsyndromal
%~