RT Journal Article
T1 Evolution of Metastasis Study Models toward Metastasis-On-A-Chip: The Ultimate Model?
A1 Ruiz-Espigares, Jesús
A1 Nieto, Daniel
A1 Moroni, Lorenzo
A1 Jiménez, Gema
A1 Marchal, Juan Antonio
K1 3D bioprinting
K1 Cancer
K1 Metastasis
K1 Metastasis-on-a-chip
K1 Tumor-on-a-chip
K1 Bioimpresión
K1 Impresión tridimensional
K1 Microambiente tumoral
AB For decades, several attempts have been made to obtain a mimetic model for the study of metastasis, the reason of most of deaths caused by cancer, in order to solve the unknown phenomena surrounding this disease. To better understand this cellular dissemination process, more realistic models are needed that are capable of faithfully recreating the entire and essential tumor microenvironment (TME). Thus, new tools known as tumor-on-a-chip and metastasis-on-a-chip have been recently proposed. These tools incorporate microfluidic systems and small culture chambers where TME can be faithfully modeled thanks to 3D bioprinting. In this work, a literature review has been developed about the different phases of metastasis, the remaining unknowns and the use of new models to study this disease. The aim is to provide a global vision of the current panorama and the great potential that these systems have for in vitro translational research on the molecular basis of the pathology. In addition, these models will allow progress toward a personalized medicine, generating chips from patient samples that mimic the original tumor and the metastatic process to perform a precise pharmacological screening by establishing the most appropriate treatment protocol.
PB Wiley-VCH Verlag GmbH & Co. KGaA
SN 1613-6810
YR 2021
FD 2021-03-11
LK http://hdl.handle.net/10668/4271
UL http://hdl.handle.net/10668/4271
LA en
NO Ruiz-Espigares J, Nieto D, Moroni L, Jiménez G, Marchal JA. Evolution of Metastasis Study Models toward Metastasis-On-A-Chip: The Ultimate Model? Small. 2021 Apr;17(14):e2006009
DS RISalud
RD Apr 11, 2025