RT Journal Article
T1 Immune mechanisms associated with cardiovascular disease in systemic lupus erythematosus: A path to potential biomarkers.
A1 Guzmán-Martínez, Gabriela
A1 Marañón, Concepción
A1 CYTED RIBLES Network, 
K1 autoantibodies
K1 biomarkers
K1 cardiovascular disease
K1 cytokines
K1 inflammation
K1 systemic lupus erythematosus
AB Systemic lupus erythematosus (SLE) patients display an increased risk of cardiovascular disease (CVD). With the improved clinical management of other classical severe manifestation of the disease, CVD is becoming one of the most relevant complications of SLE, and it is an important factor causing morbidity and mortality. Several immune constituents have been shown to be involved in the pathogenesis of atherosclerosis and endothelial damage in SLE patients, including specific circulating cell populations, autoantibodies, and inflammatory mediators. In this review, we summarize the presentation of CVD in SLE and the role of the autoimmune responses present in SLE patients in the induction of atherogenesis, endothelial impairment and cardiac disease. Additionally, we discuss the utility of these immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.
YR 2022
FD 2022-11-07
LK http://hdl.handle.net/10668/20592
UL http://hdl.handle.net/10668/20592
LA en
DS RISalud
RD Apr 19, 2025