RT Journal Article
T1 Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification
A1 Gallardo-Escribano, Cristina
A1 Buonaiuto, Verónica
A1 Ruiz-Moreno, M. Isabel
A1 Vargas-Candela, Antonio
A1 Vilches-Perez, Alberto
A1 Benitez-Porres, Javier
A1 Romance-Garcia, Angel Ramon
A1 Ruiz-Moreno, Alejandro
A1 Gómez-Huelgas, Ricardo
A1 Bernal-Lopez, M. Rosa
K1 Prepubertal population
K1 Metabolically healthy obesity
K1 Methylation
K1 Lipid profile
K1 Inflammatory profile
K1 Lifestyle modification
K1 Obesity
K1 Obesidad metabólica benigna
K1 Metilación
K1 Obesidad
K1 Niño
K1 Niño preescolar
K1 Inflamación
K1 Lípidos
K1 Estilo de vida saludable
AB Background: Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program. Results: The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet. Conclusions: It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA.
PB BioMed Central, Springer Nature
YR 2020
FD 2020-09-23
LK http://hdl.handle.net/10668/4397
UL http://hdl.handle.net/10668/4397
LA en
NO Gallardo-Escribano C, Buonaiuto V, Ruiz-Moreno MI, Vargas-Candela A, Vilches-Perez A, Benitez-Porres J, et al. Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification. Clin Epigenetics. 2020 Sep 23;12(1):144
DS RISalud
RD Apr 11, 2025