RT Journal Article
T1 Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
A1 Ocaña-Wilhelmi, Luis
A1 Martín-Núñez, Gracia María
A1 Ruiz-Limón, Patricia
A1 Alcaide, Juan
A1 García-Fuentes, Eduardo
A1 Gutiérrez-Repiso, Carolina
A1 Tinahones, Francisco J.
A1 Moreno-Indias, Isabel
K1 Bile acids
K1 Bariatric surgery
K1 Gut microbiota
K1 Enterobacteriaceae
K1 Ácidos y sales biliares
K1 Cirugía bariátrica
K1 Microbioma gastrointestinal
K1 Probióticos
K1 Obesidad
AB Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the Enterobacteriaceae family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. Blautia and Veillonella were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics.
PB MDPI
YR 2021
FD 2021-10-27
LK http://hdl.handle.net/10668/4283
UL http://hdl.handle.net/10668/4283
LA en
NO Ocaña-Wilhelmi L, Martín-Núñez GM, Ruiz-Limón P, Alcaide J, García-Fuentes E, Gutiérrez-Repiso C, et al. Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity. Metabolites. 2021 Oct 27;11(11):733
DS RISalud
RD Apr 7, 2025