TY  - JOUR
AU  - Sanchez-Varo, Raquel
AU  - Sanchez-Mejias, Elisabeth
AU  - Fernandez-Valenzuela, Juan Jose
AU  - De Castro, Vanessa
AU  - Mejias-Ortega, Marina
AU  - Gomez-Arboledas, Angela
AU  - Jimenez, Sebastian
AU  - Sanchez-Mico, Maria Virtudes
AU  - Trujillo-Estrada, Laura
AU  - Moreno-Gonzalez, Ines
AU  - Baglietto-Vargas, David
AU  - Vizuete, Marisa
AU  - Davila, Jose Carlos
AU  - Vitorica, Javier
AU  - Gutierrez, Antonia
PY  - 2021
DO  - 10.3389/fnins.2021.752594
UR  - http://hdl.handle.net/10668/4098
T2  - Frontiers in Neuroscience
AB  - Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best...
LA  - en
PB  - Frontiers
KW  - Alzheimer’s disease
KW  - Synaptic pathology
KW  - Hippocampus
KW  - Transgenic mice (Tg)
KW  - Amyloid
KW  - Oligomers
KW  - Enfermedad de Alzheimer
KW  - Hipocampo
KW  - Ratones transgénicos
KW  - Amiloide
KW  - Morfolinos
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Persons::Persons::Age Groups::Infant
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Plaque, Amyloid
KW  - Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases::Tauopathies::Alzheimer Disease
KW  - Medical Subject Headings::Anatomy::Nervous System::Neurons::Neurofibrils::Neurofibrillary Tangles
KW  - Medical Subject Headings::Anatomy::Nervous System::Synapses::Presynaptic Terminals
KW  - Medical Subject Headings::Anatomy::Nervous System::Neurons::Nerve Fibers::Axons::Neurites
KW  - Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Astrocytes
KW  - Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Elementary Particles::Electrons
KW  - Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Microglia
KW  - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
KW  - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Microscopy::Microscopy, Electron
TI  - Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
TY  - research article
ER  -