RT Journal Article T1 Metabolic Classification and Intervention Opportunities for Tumor Energy Dysfunction. A1 Monferrer, Ezequiel A1 Vieco-Martí, Isaac A1 López-Carrasco, Amparo A1 Fariñas, Fernando A1 Abanades, Sergio A1 de la Cruz-Merino, Luis A1 Noguera, Rosa A1 Álvaro Naranjo, Tomás K1 tumor ecosystem K1 tumor microenvironment K1 tumor reprogramming AB A comprehensive view of cell metabolism provides a new vision of cancer, conceptualized as tissue with cellular-altered metabolism and energetic dysfunction, which can shed light on pathophysiological mechanisms. Cancer is now considered a heterogeneous ecosystem, formed by tumor cells and the microenvironment, which is molecularly, phenotypically, and metabolically reprogrammable. A wealth of evidence confirms metabolic reprogramming activity as the minimum common denominator of cancer, grouping together a wide variety of aberrations that can affect any of the different metabolic pathways involved in cell physiology. This forms the basis for a new proposed classification of cancer according to the altered metabolic pathway(s) and degree of energy dysfunction. Enhanced understanding of the metabolic reprogramming pathways of fatty acids, amino acids, carbohydrates, hypoxia, and acidosis can bring about new therapeutic intervention possibilities from a metabolic perspective of cancer. SN 2218-1989 YR 2021 FD 2021-04-23 LK http://hdl.handle.net/10668/17701 UL http://hdl.handle.net/10668/17701 LA en DS RISalud RD Feb 15, 2025