RT Journal Article
T1 Tumor microenvironment and immune effects of antineoplastic therapy in lymphoproliferative syndromes.
A1 Alvaro, Tomás
A1 Cruz-Merino, Luis de la
A1 Henao-Carrasco, Fernando
A1 Villar Rodríguez, José Luis
A1 Vicente Baz, David
A1 Codes Manuel de Villena, Manuel
A1 Provencio, Mariano
K1 Antineoplásicos
K1 Humanos
K1 Trastornos linfoproliferativos
K1 Microambiente tumoral
K1 Animales
AB Lymphomas represent a wide group of heterogenic diseases with different biological and clinical behavior. The underlying microenvironment-specific composition seems to play an essential role in this scenario, harboring the ability to develop successful immune responses or, on the contrary, leading to immune evasion and even promotion of tumor growth. Depending on surrounding lymphoid infiltrates, lymphomas may have different prognosis. Moreover, recent evidences have emerged that confer a significant impact of main lymphoma's treatment over microenvironment, with clinical consequences. In this review, we summarize these concepts from a pathological and clinical perspective. Also, the state of the art of lymphoma's anti-idiotype vaccine development is revised, highlighting the situations where this strategy has proven to be successful and eventual clues to obtain better results in the future.
PB Hindawi Publishing Corporation
SN 1110-7243
YR 2010
FD 2010
LK http://hdl.handle.net/10668/1900
UL http://hdl.handle.net/10668/1900
LA en
NO Álvaro T, Cruz-Merino L de la , Henao-Carrasco F, Villar Rodríguez JL, Vicente Baz D, Codes Manuel de Villena M, Provencio M. Tumor microenvironment and immune effects of antineoplastic therapy in lymphoproliferative syndromes. J Biomed Biotechnol. 2010; pii: 846872
NO Journal Article; Review;
DS RISalud
RD Apr 10, 2025