RT Journal Article
T1 Late Cerebrovascular Events Following Transcatheter Aortic Valve Replacement.
A1 Muntané-Carol, Guillem
A1 Urena, Marina
A1 Munoz-Garcia, Antonio
A1 Padrón, Remigio
A1 Gutiérrez, Enrique
A1 Regueiro, Ander
A1 Serra, Vicenç
A1 Capretti, Giulianna
A1 Himbert, Dominique
A1 Moris, Cesar
A1 Sabaté, Manel
A1 Garcia Del Blanco, Bruno
A1 Ferreira-Neto, Alfredo Nunes
A1 Coté, Mélanie
A1 Fischer, Quentin
A1 Couture, Thomas
A1 Kalavrouziotis, Dimitri
A1 Rodés-Cabau, Josep
K1 cerebrovascular events
K1 stroke
K1 transcatheter aortic valve replacement
AB This study sought to determine the incidence, clinical characteristics, associated factors, and outcomes of late cerebrovascular events (LCVEs) (>30 days post-procedure) following transcatheter aortic valve replacement (TAVR). Scarce data exist on LCVEs following TAVR. This was a multicenter study including 3,750 consecutive patients (mean age, 80 ± 8 years; 50.5% of women) who underwent TAVR and survived beyond 30 days. LCVEs were defined according to the Valve Academic Research Consortium 2 (VARC 2) criteria. LCVEs occurred in 192 (5.1%) patients (stroke, 80.2%; transient ischemic attack, 19.8%) after a median follow-up of 2 (1 to 4) years. Late stroke was of ischemic, hemorrhagic, and undetermined origin in 80.5%, 18.8%, and 0.7% of patients, respectively. Older age, previous cerebrovascular disease, higher mean aortic gradient at baseline, the occurrence of stroke during the periprocedural TAVR period, and the lack of anticoagulation (novel oral anticoagulants or vitamin K antagonists) post-TAVR were independent factors associated with late ischemic stroke/transient ischemic attack (p  LCVEs occurred in 5.1% of TAVR recipients after a median follow-up of 2 years. LCVEs were ischemic in most cases, with older age, previous cerebrovascular events, higher mean aortic gradient at baseline, the occurrence during the periprocedural TAVR period, and lack of anticoagulation (but not valve thrombosis/degeneration) determining an increased risk. Late stroke was disabling in most cases and associated with dreadful early and midterm outcomes.
YR 2020
FD 2020-03-11
LK http://hdl.handle.net/10668/15239
UL http://hdl.handle.net/10668/15239
LA en
DS RISalud
RD Apr 7, 2025