RT Journal Article
T1 Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.
A1 Ziv, Elad
A1 Dean, Eric
A1 Hu, Donglei
A1 Martino, Alessandro
A1 Serie, Daniel
A1 Curtin, Karen
A1 Campa, Daniele
A1 Aftab, Blake
A1 Bracci, Paige
A1 Buda, Gabriele
A1 Zhao, Yi
A1 Caswell-Jin, Jennifer
A1 Diasio, Robert
A1 Dumontet, Charles
A1 Dudziński, Marek
A1 Fejerman, Laura
A1 Greenberg, Alexandra
A1 Huntsman, Scott
A1 Jamroziak, Krzysztof
A1 Jurczyszyn, Artur
A1 Kumar, Shaji
A1 Atanackovic, Djordje
A1 Glenn, Martha
A1 Cannon-Albright, Lisa A
A1 Jones, Brandt
A1 Lee, Adam
A1 Marques, Herlander
A1 Martin, Thomas
A1 Martinez-Lopez, Joaquin
A1 Rajkumar, Vincent
A1 Sainz, Juan
A1 Vangsted, Annette Juul
A1 Wątek, Marzena
A1 Wolf, Jeffrey
A1 Slager, Susan
A1 Camp, Nicola J
A1 Canzian, Federico
A1 Vachon, Celine
AB Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.
PB Nature Publishing Group
YR 2015
FD 2015-07-22
LK http://hdl.handle.net/10668/2290
UL http://hdl.handle.net/10668/2290
LA en
NO Ziv E, Dean E, Hu D, Martino A, Serie D, Curtin K, et al. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients. Nat Commun. 2015; 6:7539
NO Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 10, 2025