TY  - JOUR
AU  - Pineda de las Infantas y Villatoro, Maria J
AU  - Unciti-Broceta, Juan D
AU  - Contreras-Montoya, Rafael
AU  - Garcia-Salcedo, Jose A
AU  - Gallo Mezo, Miguel A
AU  - Unciti-Broceta, Asier
AU  - Diaz-Mochon, Juan J
PY  - 2015
DO  - 10.1038/srep09139
UR  - http://hdl.handle.net/10668/2376
T2  - Scientific Reports
AB  - A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff...
LA  - en
PB  - Nature Publishing Group
KW  - Técnicas de químicas  sintética
KW  - Purinas
KW  - Tripanocidas
KW  - Trypanosoma brucei brucei
KW  - Amidas
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiparasitic Agents::Antiprotozoal Agents::Trypanocidal Agents
KW  - Medical Subject Headings::Organisms::Eukaryota::Euglenozoa::Kinetoplastida::Trypanosomatina::Trypanosoma::Trypanosoma brucei brucei
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides
KW  - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Organic Chemistry Phenomena::Organic Chemistry Processes::Chemistry Techniques, Synthetic
TI  - Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity.
TY  - research article
ER  -