RT Journal Article
T1 Changes in Gut Microbiota Induced by Doxycycline Influence in Vascular Function and Development of Hypertension in DOCA-Salt Rats.
A1 Robles-Vera, Iñaki
A1 de la Visitación, Néstor
A1 Toral, Marta
A1 Sánchez, Manuel
A1 Romero, Miguel
A1 Gómez-Guzmán, Manuel
A1 Vargas, Félix
A1 Duarte, Juan
A1 Jiménez, Rosario
K1 DOCA-salt model
K1 doxycycline
K1 gut dysbiosis
K1 hypertension
K1 inflammation
K1 oxidative stress
AB Previous experiments in animals and humans show that shifts in microbiota and its metabolites are linked to hypertension. The present study investigates whether doxycycline (DOX, a broad-spectrum tetracycline antibiotic) improves dysbiosis, prevent cardiovascular pathology and attenuate hypertension in deoxycorticosterone acetate (DOCA)-salt rats, a renin-independent model of hypertension. Male Wistar rats were randomly assigned to three groups: control, DOCA-salt hypertensive rats, DOCA-salt treated with DOX for 4 weeks. DOX decreased systolic blood pressure, improving endothelial dysfunction and reducing aortic oxidative stress and inflammation. DOX decreased lactate-producing bacterial population and plasma lactate levels, improved gut barrier integrity, normalized endotoxemia, plasma noradrenaline levels and restored the Treg content in aorta. These data demonstrate that DOX through direct effects on gut microbiota and its non-microbial effects (anti-inflammatory and immunomodulatory) reduces endothelial dysfunction and the increase in blood pressure in this low-renin form of hypertension.
YR 2021
FD 2021-08-26
LK https://hdl.handle.net/10668/25296
UL https://hdl.handle.net/10668/25296
LA en
DS RISalud
RD Apr 12, 2025