RT Journal Article
T1 Leisure time physical activity is associated with improved HDL functionality in high cardiovascular risk individuals: a cohort study
A1 Hernaez, Alvaro
A1 Soria-Florido, Maria Trinidad
A1 Castaner, Olga
A1 Pinto, Xavier
A1 Estruch, Ramon
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Alonso-Gomez, Angel
A1 Angel Martinez-Gonzalez, Miguel
A1 Schroder, Helmut
A1 Ros, Emilio
A1 Serra-Majem, Lluis
A1 Fiol, Miguel
A1 Lapetra, Jose
A1 Gomez-Gracia, Enrique
A1 Fito, Montserrat
A1 Lassale, Camille
K1 HDL function
K1 physical activity
K1 lifestyle
K1 biomarkers
K1 High-density-lipoprotein
K1 Activity questionnaire
K1 Heart-disease
K1 Exercise
K1 Ampk
K1 Cholesterol
K1 Validation
K1 Protein
K1 Events
AB AimsPhysical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits.MethodsThe study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors.ResultsHigher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity.ConclusionsIn a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.
PB Oxford univ press
SN 2047-4873
YR 2020
FD 2020-06-02
LK http://hdl.handle.net/10668/19106
UL http://hdl.handle.net/10668/19106
LA en
DS RISalud
RD Apr 10, 2025