RT Journal Article
T1 The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes.
A1 Camarillo, Rosa
A1 Jimeno, Sonia
A1 Huertas, Pablo
K1 DNA double strand break repair
K1 DNA end resection
K1 G-quadruplex
K1 R-loops
K1 homologous recombination (HR)
AB The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.
SN 1664-8021
YR 2021
FD 2021-10-08
LK https://hdl.handle.net/10668/28366
UL https://hdl.handle.net/10668/28366
LA en
DS RISalud
RD Apr 6, 2025