%0 Journal Article
%A Camarillo, Rosa
%A Jimeno, Sonia
%A Huertas, Pablo
%T The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes.
%D 2021
%@ 1664-8021
%U https://hdl.handle.net/10668/28366
%X The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.
%K DNA double strand break repair
%K DNA end resection
%K G-quadruplex
%K R-loops
%K homologous recombination (HR)
%~