RT Journal Article
T1 Plasma carotenoids, vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort.
A1 Bakker, Marije F
A1 Peeters, Petra Hm
A1 Klaasen, Veronique M
A1 Bueno-de-Mesquita, H Bas
A1 Jansen, Eugene Hjm
A1 Ros, Martine M
A1 Travier, Noémie
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Overvad, Kim
A1 Rinaldi, Sabina
A1 Romieu, Isabelle
A1 Brennan, Paul
A1 Boutron-Ruault, Marie-Christine
A1 Perquier, Florence
A1 Cadeau, Claire
A1 Boeing, Heiner
A1 Aleksandrova, Krasimira
A1 Kaaks, Rudolf
A1 Kühn, Tilman
A1 Trichopoulou, Antonia
A1 Lagiou, Pagona
A1 Trichopoulos, Dimitrios
A1 Vineis, Paolo
A1 Krogh, Vittorio
A1 Panico, Salvatore
A1 Masala, Giovanna
A1 Tumino, Rosario
A1 Weiderpass, Elisabete
A1 Skeie, Guri
A1 Lund, Eiliv
A1 Quirós, J Ramón
A1 Ardanaz, Eva
A1 Navarro, Carmen
A1 Amiano, Pilar
A1 Sanchez-Perez, Maria-Jose
A1 Buckland, Genevieve
A1 Ericson, Ulrika
A1 Sonestedt, Emily
A1 Johansson, Matthias
A1 Sund, Malin
A1 Travis, Ruth C
A1 Key, Timothy J
A1 Khaw, Kay-Tee
A1 Wareham, Nick
A1 Riboli, Elio
A1 van Gils, Carla H
K1 EPIC
K1 antioxidants
K1 breast cancer
K1 carotenoids
K1 plasma
AB Carotenoids and vitamin C are thought to be associated with reduced cancer risk because of their antioxidative capacity. This study evaluated the associations of plasma carotenoid, retinol, tocopherol, and vitamin C concentrations and risk of breast cancer. In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort, 1502 female incident breast cancer cases were included, with an oversampling of premenopausal (n = 582) and estrogen receptor-negative (ER-) cases (n = 462). Controls (n = 1502) were individually matched to cases by using incidence density sampling. Prediagnostic samples were analyzed for α-carotene, β-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, retinol, α-tocopherol, γ-tocopherol, and vitamin C. Breast cancer risk was computed according to hormone receptor status and age at diagnosis (proxy for menopausal status) by using conditional logistic regression and was further stratified by smoking status, alcohol consumption, and body mass index (BMI). All statistical tests were 2-sided. In quintile 5 compared with quintile 1, α-carotene (OR: 0.61; 95% CI: 0.39, 0.98) and β-carotene (OR: 0.41; 95% CI: 0.26, 0.65) were inversely associated with risk of ER- breast tumors. The other analytes were not statistically associated with ER- breast cancer. For estrogen receptor-positive (ER+) tumors, no statistically significant associations were found. The test for heterogeneity between ER- and ER+ tumors was statistically significant only for β-carotene (P-heterogeneity = 0.03). A higher risk of breast cancer was found for retinol in relation to ER-/progesterone receptor-negative tumors (OR: 2.37; 95% CI: 1.20, 4.67; P-heterogeneity with ER+/progesterone receptor positive = 0.06). We observed no statistically significant interaction between smoking, alcohol, or BMI and all investigated plasma analytes (based on tertile distribution). Our results indicate that higher concentrations of plasma β-carotene and α-carotene are associated with lower breast cancer risk of ER- tumors.
YR 2016
FD 2016-01-20
LK http://hdl.handle.net/10668/9755
UL http://hdl.handle.net/10668/9755
LA en
DS RISalud
RD Apr 7, 2025