RT Journal Article T1 Effects of High-Intensity Interval Training on Inflammatory Biomarkers in Patients with Type 2 Diabetes. A Systematic Review A1 Leiva-Valderrama, Jose Manuel A1 Montes-de-Oca-Garcia, Adrian A1 Opazo-Diaz, Edgardo A1 Ponce-Gonzalez, Jesus G. A1 Molina-Torres, Guadalupe A1 Velazquez-Diaz, Daniel A1 Galan-Mercant, Alejandro K1 HIIT K1 T2D K1 inflammatory biomarkers K1 Body-composition K1 Exercise K1 Risk K1 Obesity K1 Health K1 Individuals K1 Responses K1 Link AB Background: Due to the prevalence and incidence worldwide of type 2 diabetes, and the significant role physical activity plays in these patients, a systematic review has been conducted to find out the effects that high-intensity interval training has on inflammatory biomarkers in subjects with type 2 diabetes. This project aims to determine the effect this training modality has on inflammatory biomarkers, in addition to observing its effects on the values of body composition and determining if this is a more effective, less effective or equally effective alternative to standard aerobic or resistance training. Methods: A search was conducted in the months of November and December 2020 on different databases: Pubmed, WoS and PEDro. A protocol for this systematic review was registered in PROSPERO (Registration number: CRD42021281186). The studies selected met the previously defined inclusion criteria, and the methodological quality of the papers used was evaluated according to the Downs and Black Checklist. Results: Out of 46 studies found, seven were included. The most relevant data concerning the characteristics of the clinical trials and HIIT characteristics, the values of body composition and the biomarkers under study were extracted from each study. Moreover, the results obtained from the different studies were described. Conclusions: HIIT could have an effect on inflammatory biomarkers. There is likely to be a relationship between changes in inflammatory profile and fat loss. A controlled diet may be a good complement to reduce the inflammatory profile. Further studies are required to determine whether HIIT is a better, worse or an equivalent alternative to medium-intensity aerobic exercise to improve the inflammatory profile. PB Mdpi YR 2021 FD 2021-12-01 LK https://hdl.handle.net/10668/25239 UL https://hdl.handle.net/10668/25239 LA en DS RISalud RD Apr 9, 2025